Apilimod

• CAS Number :

  541550-19-0

• Synonyms :

  STA-5326

• SKU :

  C11871-5mg

• Target :

  PIKfyve

• Applications :

  PI3K/Akt/mTOR

• Smiles :

  CC1=CC (=CC=C1) C=NNC2=CC (=NC (=N2) OCCC3=CC=CC=N3) N4CCOCC4

• Molecular Formula :

  C23H26N6O2

• Additionnal Information :

  Apilimod is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod (STA-5326) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.

• Storage Conditions :

  3 years -20°C powder