Apilimod (hydrochloride)

Apilimod (hydrochloride)

• CAS Number: 870087-37-9
• UNSPSC Description: Apilimod (STA 5326) hydrochloride is a PIKFYVE kinase inhibitor that promotes NLRP3 inflammatory vesicle activation and IL-1β secretion. Apilimod hydrochloride has been shown to inhibit host cell proteases, which may prevent viral invasion but also block antiviral immune responses, potentially exacerbating immunosuppression in COVID-19.
• Target Antigen: NOD-like Receptor (NLR)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-anti-virus
• Field of Research: Infection; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/apilimod-hydrochloride.html
• Smiles: CC1=CC=CC(/C=N/NC2=CC(N3CCOCC3)=NC(OCCC4=CC=CC=N4)=N2)=C1.Cl.Cl
• Molecular Weight: 491.41
• References & Citations: [1]The PIKfyve Inhibitor Apilimod: A Double-Edged Sword against COVID-19
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported