PF-477736

• CAS Number :

  952021-60-2

• Synonyms :

  PF-736, PF-00477736

• SKU :

  C08953-5mg

• Target :

  Chk

• Applications :

  Cell Cycle

• Smiles :

  CN1C=C (C=N1) C2=C3C=NNC (=O) C4=C3C (=CC (=C4) NC (=O) C (C5CCCCC5) N) N2

• Molecular Formula :

  C22H25N7O2

• Additionnal Information :

  PF-477736 (PF-736, PF-00477736) is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2.

• Storage Conditions :

  2 years -80 in solvent