Niraparib (MK-4827)

• CAS Number :

  1038915-60-4

• SKU :

  C08818-5mg

• Target :

  PARP

• Applications :

  DNA Damage/DNA Repair

• Smiles :

  C1CC (CNC1) C2=CC=C (C=C2) N3C=C4C=CC=C (C4=N3) C (=O) N

• Molecular Formula :

  C19H20N4O

• Additionnal Information :

  Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Niraparib can form PARP–DNA complexes resulting in DNA damage, apoptosis, and cell death. Phase 3.

• Storage Conditions :

  2 years -80 in solvent