LDN-193189

• CAS Number :

  1062368-24-4

• Synonyms :

  DM3189

• SKU :

  C08723-2mg

• Target :

  TGF-beta/Smad

• Applications :

  TGF-beta/Smad

• Smiles :

  C1CN (CCN1) C2=CC=C (C=C2) C3=CN4C (=C (C=N4) C5=CC=NC6=CC=CC=C56) N=C3

• Molecular Formula :

  C25H22N6

• Additionnal Information :

  LDN-193189 (DM3189) is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. For cell testing, the water-soluble S7507 LDN-193189 2HCl is recommended.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!

• Storage Conditions :

  2 years -80 in solvent