Adezmapimod (SB203580)

• CAS Number :

  152121-47-6

• Synonyms :

  RWJ 64809, PB 203580

• SKU :

  C07496-25mg

• Target :

  P38 MAPK

• Applications :

  MAPK

• Smiles :

  CS (=O) C1=CC=C (C=C1) C2=NC (=C (N2) C3=CC=NC=C3) C4=CC=C (C=C4) F

• Molecular Formula :

  C21H16FN3OS

• Additionnal Information :

  Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3 (106T) and SAPK4 (106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.

• Storage Conditions :

  3 years-20°C (in the dark) powder