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Adezmapimod (hydrochloride) (Standard)

CAT: 0804-HY-10256AR-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10256AR-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Adezmapimod (hydrochloride) (Standard) is the analytical standard of Adezmapimod (hydrochloride) . This product is intended for research and analytical applications. Adezmapimod (SB 203580; RWJ 64809) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride does not disrupt JNK activity and is an autophagy and mitophagy activator[1].
CAS Number
869185-85-3
Product Name Alternative
SB 203580 (hydrochloride) (Standard) ; RWJ 64809 (hydrochloride) (Standard)
UNSPSC
12352005
Target
Autophagy; Mitophagy; Organoid; p38 MAPK; Reference Standards
Related Pathways
Autophagy; MAPK/ERK Pathway; Others; Stem Cell/Wnt
Field of Research
Inflammation/Immunology; Cancer
Smiles
O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C.[H]Cl
Molecular Formula
C21H17ClFN3OS
Molecular Weight
413.90
References & Citations
[1]Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351 (Pt 1) :95-105.|[2]Lali FV, et al. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J Biol Chem. 2000 Mar 10;275 (10) :7395-402.|[3]Leelahavanichkul K, et al. A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis. Mol Oncol. 2014 Feb;8 (1) :105-18.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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