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PT-179

CAT: 1568-C01964-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:1568-C01964-02Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2924858-25-1
SKU
C01964-5mg
Target
E3 Ligase
Applications
Ubiquitin
Additionnal Information
PT-179, an orthogonal Thalidomide derivative targets cereblon without causing off-target degradation effects. PT-179 specifically binds CRBN, forms a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediates the degradation of the tagged protein.

Chemical Information

2-(2,6-Dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione
CAS Number2924858-25-1
PubChem CID163294079
IUPAC Name2-(2,6-dioxopiperidin-3-yl)-5-morpholin-4-ylisoindole-1,3-dione
Molecular FormulaC17H17N3O5
Molecular Weight343.33
XLogP0.1
Topological Polar Surface Area96
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count25
Formal Charge0
Complexity615
SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)N4CCOCC4
InChI
InChI=1S/C17H17N3O5/c21-14-4-3-13(15(22)18-14)20-16(23)11-2-1-10(9-12(11)17(20)24)19-5-7-25-8-6-19/h1-2,9,13H,3-8H2,(H,18,21,22)
InChIKey
CCCSRHUSXCBFJZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(2,6-Dioxopiperidin-3-yl)-5-morpholinoisoindoline-1,3-dione
CAS: 2924858-25-1
CID: 163294079
Formula: C17H17N3O5
MW: 343.33
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight343.33
XLogP30.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass343.11682065
Monoisotopic Mass343.11682065
Topological Polar Surface Area96 Ų
Heavy Atom Count25
Formal Charge0
Complexity615
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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