ML133 (hydrochloride)

• Description :

  ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H318, H335, H400

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/ml133-hydrochloride.html

• Purity :

  99.82

• Solubility :

  DMSO : 87.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  COC1=CC=C(CNCC2=C3C=CC=CC3=CC=C2)C=C1.[H]Cl

• Molecular Formula :

  C19H20ClNO

• Molecular Weight :

  313.82

• Precautions :

  H302, H315, H318, H335, H400

• References & Citations :

  [1]Wang HR, et al. Selective inhibition of the K (ir) 2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem Biol. 2011 Aug 19;6 (8) :845-56.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1222781-70-5]