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Olgotrelvir (sodium)

CAT: 0804-HY-156655A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-156655A-01Size:1 mg
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Description
Olgotrelvir (STI-1558) sodium is an orally active dual inhibitor of coronavirus main protease (Mpro) and human cell cathepsin (Cathepsin L) . Olgotrelvir sodium is readily converted to its active form, AC1115, in full blood and/or plasma. Olgotrelvir sodium can effectively inhibit both SARS-CoV-2 replication and entry into host cells[1][2].
CAS Number
2763596-72-9
Product Name Alternative
STI-1558 (sodium)
UNSPSC
12352005
Target
Cathepsin; SARS-CoV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/olgotrelvir-sodium.html
Purity
95.0
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(NCC1)[C@@H]1C[C@@H](C(O)S(=O)(O[Na])=O)NC([C@H](CC(C)C)NC(C2=CC3=CC=CC=C3N2)=O)=O
Molecular Formula
C22H29N4NaO7S
Molecular Weight
516.54
References & Citations
[1]Sorrento Announces the Full Enrollment of the Pivotal Phase 3 Trial with Olgotrelvir (OVYDSOTM) (STI-1558), a Second Generation Oral Mpro Inhibitor, as a Standalone Treatment for COVID-19.|[2]Mao L, et al. Olgotrelvir, a dual inhibitor of SARS-CoV-2 Mpro and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19. Med. 2024 Feb 9;5 (2) :169-171.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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