(2R,3S)-E1R

• Product Name Alternative:

  MK-0869; MK-869; L-754030

• UNSPSC Description:

  (2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. (2R,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1].

• Target Antigen:

  Sigma Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/2r-3s-e1r.html

• Purity:

  98.84

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C(N)CN1[C@H](C)[C@H](C2=CC=CC=C2)CC1=O

• Molecular Weight:

  232.283

• References & Citations:

  [1]Veinberg G, et al. Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21(10):2764-71.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1424832-60-9