E1R

• Description :

  E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity[1].

• Product Name Alternative :

  MK-0869; MK-869; L-754030

• UNSPSC :

  12352005

• Target :

  Sigma Receptor

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/e1r.html

• Concentration :

  10mM

• Purity :

  99.83

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(CN1C(C[C@@H]([C@@H]1C)C2=CC=CC=C2)=O)N

• Molecular Formula :

  C13H16N2O2

• Molecular Weight :

  232.28

• References & Citations :

  [1]Zvejniece L, et al. The cognition-enhancing activity of E1R, a novel positive allosteric modulator of sigma-1 receptors. Br J Pharmacol. 2014 Feb;171 (3) :761-71.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Sigma 1 Receptor

• CAS Number :

  [1301211-78-8]