E1R

• Description:

  E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity[1].

• Product Name Alternative:

  MK-0869; MK-869; L-754030

• UNSPSC:

  12352005

• Target:

  Sigma Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/e1r.html

• Concentration:

  10mM

• Purity:

  99.83

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (CN1C (C[C@@H] ([C@@H]1C) C2=CC=CC=C2) =O) N

• Molecular Formula:

  C13H16N2O2

• Molecular Weight:

  232.28

• References & Citations:

  [1]Zvejniece L, et al. The cognition-enhancing activity of E1R, a novel positive allosteric modulator of sigma-1 receptors. Br J Pharmacol. 2014 Feb;171 (3) :761-71.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Sigma 1 Receptor

• CAS Number:

  1301211-78-8