(2R,3R) -E1R

• Description :

  (2R,3R) -E1R (Compound 2b) is an enantiomer of E1R. (2R,3R) -E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1].

• UNSPSC :

  12352005

• Target :

  Sigma Receptor

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/2r-3r-e1r.html

• Purity :

  98.79

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(N)CN1[C@H](C)[C@@H](C2=CC=CC=C2)CC1=O

• Molecular Formula :

  C13H16N2O2

• Molecular Weight :

  232.28

• References & Citations :

  [1]Veinberg G, et al. Synthesis and biological evaluation of 2- (5-methyl-4-phenyl-2-oxopyrrolidin-1-yl) -acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21 (10) :2764-71.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Sigma 1 Receptor

• CAS Number :

  [1400888-63-2]