CD73-IN-5

• Description :

  CD73-IN-5 is a potent and selective non-nucleotide small molecule inhibitor of CD73 (IC50 = 19 nM) .

• UNSPSC :

  12352005

• Target :

  CD73

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cd73-in-5.html

• Concentration :

  10mM

• Purity :

  98.04

• Solubility :

  DMSO : ≥ 50 mg/mL

• Smiles :

  N#CC1=CC=C(CN2N=CC=C2C3=CC4=C(N=NN4C5=CC6=C(C=NN6)C=C5)C(F)=C3)C=C1

• Molecular Formula :

  C24H15FN8

• Molecular Weight :

  434.43

• References & Citations :

  [1]Beatty JW, et al. Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73. J Med Chem. 2020 Apr 23;63 (8) :3935-3955.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2412019-99-7]