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DiSC3 (5)

CAT: 0804-HY-D0085-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D0085-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DiSC3 (5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3 (5) is up to 622/670 nm. DiSC3 (5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC50 value is 8 μM. DiSC3 (5) in the presence of Na+/K+-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells[1][2][3].
CAS Number
53213-94-8
UNSPSC
12171500
Hazard Statement
H315, H319, H335
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/disc3-5.html
Purity
99.83
Solubility
DMSO : 5.83 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCCN1/C(SC2=CC=CC=C12)=C\C=C\C=C\C3=[N+](CCC)C4=CC=CC=C4S3.[I-]
Molecular Formula
C25H27IN2S2
Molecular Weight
546.53
Precautions
H315, H319, H335
References & Citations
[1]Yamamoto T, et al. Multiple effects of DiS-C3 (5) on mitochondrial structure and function. Eur J Biochem. 2004;271 (17) :3573-3579. |[2]Sims PJ, et al. Studies on the mechanism by which cyanine dyes measure membrane potential in red blood cells and phosphatidylcholine vesicles. Biochemistry. 1974 Jul 30;13 (16) :3315-30.|[3]Smith TC, et al. The effect of the fluorescent probe, 3,3'-dipropylthiodicarbocyanine iodide, on the membrane potential of Ehrlich ascites tumor cells. Biochem Biophys Res Commun. 1980 Jul 31;95 (2) :722-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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