13-Hydroxyisobakuchiol

• Description :

  Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM) . 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease and depression[1].

• Product Name Alternative :

  Delta3,2-Hydroxylbakuchiol

• UNSPSC :

  12352005

• Target :

  Dopamine Transporter; Monoamine Transporter

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/13-hydroxyisobakuchiol.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=CC=C(/C=C/[C@](C)(C=C)C/C=C/C(C)(O)C)C=C1

• Molecular Formula :

  C18H24O2

• Molecular Weight :

  272.38

• References & Citations :

  [1]Gang Zhao, et al. Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions. Biochem Pharmacol. 2008 May 1;75 (9) :1835-47.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [178765-49-6]