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XAV-939

CAT: 0804-HY-15147-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15147-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XAV-939 is a Tankyrase inhibitor. XAV-939 has inhibitory activity for TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively. XAV-939 also is an enhancer of osteoblastic differentiation of hMSCs. XAV-939 can be used for the research of conditions associated with activated Wnt signaling, such as cancer, fibrotic diseases and conditions associated with low bone formation[1][2][3].
CAS Number
284028-89-3
UNSPSC
12352005
Hazard Statement
H301, H319
Target
PARP; β-catenin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/XAV-939.html
Purity
99.91
Solubility
DMSO : 15.62 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(CSCC2)=C2N=C(C3=CC=C(C(F)(F)F)C=C3)N1
Molecular Formula
C14H11F3N2OS
Molecular Weight
312.31
Precautions
H301, H319
References & Citations
[1]Mohit Narwal, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56 (20) :7880-9.|[2]Nuha Almasoud, et al. Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells. Sci Rep. 2020 Oct 7;10 (1) :16746. |[3]Senxin Cai, et al. Mechanical stress reduces secreted frizzled-related protein expression and promotes temporomandibular joint osteoarthritis via Wnt/β-catenin signaling. Bone. 2022 Aug;161:116445.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP2; TNKS1/PARP5A; TNKS2/PARP5B

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