Trichostatin C

Trichostatin C

• CAS Number: 68676-88-0
• UNSPSC Description: Trichostatin C is an inhibitor for histone deacetylase (HDAC), induces apoptosis and arrests cell cycle at G2/M phase, and exhibits anticancer activity against lung cancer and urothelial bladder cancer[1]. Trichostatin C induces differentation of Friend leukemic cells[2]. Trichostatin C exhibits antifungal activity[3].
• Target Antigen: Apoptosis; Fungal; HDAC
• Type: Reference compound
• Related Pathways: Anti-infection;Apoptosis;Cell Cycle/DNA Damage;Epigenetics
• Applications: COVID-19-anti-virus
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/trichostatin-c.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NO[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O)/C=C/C(C)=C/[C@@H](C)C(C2=CC=C(N(C)C)C=C2)=O
• Molecular Weight: 464.51
• References & Citations: [1]Wang C, et al., Trichostatin C Synergistically Interacts with DNMT Inhibitor to Induce Antineoplastic Effect via Inhibition of Axl in Bladder and Lung Cancer Cells[J]. Pharmaceuticals, 2024, 17(4): 425.|[2]Yoshida M, et al., Trichostatin C, a new inducer of differentiation of Friend leukemic cells[J]. Agricultural and biological chemistry, 1985, 49(2): 563-565.|[3]Tsuji N, et al., a glucopyranosyl hydroxamate. J Antibiot (Tokyo). 1978 Oct;31(10):939-44.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported