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Trichostatin C

CAT: 0804-HY-126566Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-126566Size:1 Each
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Description
Trichostatin C is an inhibitor for histone deacetylase (HDAC), induces apoptosis and arrests cell cycle at G2/M phase, and exhibits anticancer activity against lung cancer and urothelial bladder cancer[1]. Trichostatin C induces differentation of Friend leukemic cells[2]. Trichostatin C exhibits antifungal activity[3].
CAS Number
68676-88-0
UNSPSC
12352005
Target
Apoptosis; Fungal; HDAC
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/trichostatin-c.html
Solubility
10 mM in DMSO
Smiles
O=C(NO[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O)/C=C/C(C)=C/[C@@H](C)C(C2=CC=C(N(C)C)C=C2)=O
Molecular Formula
C23H32N2O8
Molecular Weight
464.51
References & Citations
[1]Wang C, et al., Trichostatin C Synergistically Interacts with DNMT Inhibitor to Induce Antineoplastic Effect via Inhibition of Axl in Bladder and Lung Cancer Cells[J]. Pharmaceuticals, 2024, 17 (4) : 425.|[2]Yoshida M, et al., Trichostatin C, a new inducer of differentiation of Friend leukemic cells[J]. Agricultural and biological chemistry, 1985, 49 (2) : 563-565.|[3]Tsuji N, et al., a glucopyranosyl hydroxamate. J Antibiot (Tokyo) . 1978 Oct;31 (10) :939-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6

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