PHGDH-IN-3

PHGDH-IN-3

• CAS Number: 2893778-31-7
• UNSPSC Description: PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-3 inhibits PHGDH with an IC50 value of 2.8 μM. PHGDH-IN-3 can be used for the research of cancer[1].
• Target Antigen: Phosphoglycerate Dehydrogenase (PHGDH)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/phgdh-in-3.html
• Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 70°C)
• Smiles: CC(C1=CC=CC(NS(=O)(C2=CC=C(C=C2)C(NC3=NC(C4=CC=CC(F)=C4)=CS3)=O)=O)=C1)=O
• Molecular Weight: 495.55
• References & Citations: [1]Dingding Gao, et al. Discovery of Novel Drug-like PHGDH Inhibitors to Disrupt Serine Biosynthesis for Cancer Therapy. J Med Chem. 2023 Jan 12;66(1):285-305.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported