EGFR-IN-154

CAT: 0804-HY-173188Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-173188Size:1 Each

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Description

EGFR-IN-154 (compound 4c) is an EGFR inhibitor with EC50 values of 0.16 μM, 21.73 μM and 41.56 μM against EGFR Del19, EGFR WT and EGFR L858R, respectively. EGFR-IN-154 shows anticancer activity on various cance cell lines. EGFR-IN-154 induces mitochondrial apoptosis, and decreases pERK1/2 and pAkt levels, but increases pJNK and pp38 levels[1].

UNSPSC

12352005

Target

Akt; EGFR; JNK; p38 MAPK; PERK

Related Pathways

Cell Cycle/DNA Damage; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

N=C(NC1CC1)C(C=C2)=CC=C2NC3=NC=NC4=C3C=C(OC)C(OC)=C4

Molecular Formula

C20H21N5O2

Molecular Weight

363.41

References & Citations

[1]Acar Halıcı C, et al. Design, synthesis, and biological evaluation of novel amidoxime or amidine analogues of some 4-anilino-6,7-dimethoxyquinazolines with a potent EGFR inhibitory effect. Bioorg Chem. 2025 May;158:108345.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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