EGFR-IN-154

• Description:

  EGFR-IN-154 (compound 4c) is an EGFR inhibitor with EC50 values of 0.16 μM, 21.73 μM and 41.56 μM against EGFR Del19, EGFR WT and EGFR L858R, respectively. EGFR-IN-154 shows anticancer activity on various cance cell lines. EGFR-IN-154 induces mitochondrial apoptosis, and decreases pERK1/2 and pAkt levels, but increases pJNK and pp38 levels[1].

• UNSPSC:

  12352005

• Target:

  Akt; EGFR; JNK; p38 MAPK; PERK

• Related Pathways:

  Cell Cycle/DNA Damage; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  N=C(NC1CC1)C(C=C2)=CC=C2NC3=NC=NC4=C3C=C(OC)C(OC)=C4

• Molecular Formula:

  C20H21N5O2

• Molecular Weight:

  363.41

• References & Citations:

  [1]Acar Halıcı C, et al. Design, synthesis, and biological evaluation of novel amidoxime or amidine analogues of some 4-anilino-6,7-dimethoxyquinazolines with a potent EGFR inhibitory effect. Bioorg Chem. 2025 May;158:108345.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported