14,15-EET-SI

14,15-EET-SI

• CAS Number: 218461-97-3
• UNSPSC Description: 14,15-EET-SI is a sulfonimide (SI) analog metabolized from 14,15-EET, which is also an effective mitogen. 14,15-EET-SI can stimulate the incorporation of [3H] thymidine, activate pp60c-src and initiate the tyrosine kinase cascade, mediating their mitotic effects. Additionally, 14,15-EET-SI can increase cell proliferation as well as the expression of c-fos and egr-1 mRNA[1].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/14-15-eet-si.html
• Solubility: 10 mM in DMSO
• Smiles: CS(NC(CCC/C=C\C/C=C\C/C=C\CC1C(O1)CCCCC)=O)(=O)=O
• Molecular Weight: 397.57
• References & Citations: [1]Chen JK, et al. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells. J Biol Chem. 1998 Oct 30;273(44):29254-61.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported