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Pyroxamide

CAT: 0804-HY-13216-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13216-05Size:50 mg
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Description
Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia[1].
CAS Number
382180-17-8
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pyroxamide.html
Purity
99.54
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NO)CCCCCCC(NC1=CC=CN=C1)=O
Molecular Formula
C13H19N3O3
Molecular Weight
265.31
Precautions
H302
References & Citations
[1]Butler LM, et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin Cancer Res. 2001 Apr;7 (4) :962-70.|[2]Kutko MC, et al. Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro.Clin Cancer Res. 2003 Nov 15;9 (15) :5749-55.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
HDAC1

Chemical Information

Pyroxamide

N'-hydroxy-N-(3-pyridinyl)octanediamide is an aromatic amide.

CAS Number382180-17-8
PubChem CID4996
IUPAC NameN'-hydroxy-N-pyridin-3-yloctanediamide
Molecular FormulaC13H19N3O3
Molecular Weight265.31
XLogP0.9
Topological Polar Surface Area91.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Heavy Atom Count19
Formal Charge0
Complexity284
SMILES
C1=CC(=CN=C1)NC(=O)CCCCCCC(=O)NO
InChI
InChI=1S/C13H19N3O3/c17-12(15-11-6-5-9-14-10-11)7-3-1-2-4-8-13(18)16-19/h5-6,9-10,19H,1-4,7-8H2,(H,15,17)(H,16,18)
InChIKey
PTJGLFIIZFVFJV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pyroxamide
CAS: 382180-17-8
CID: 4996
Formula: C13H19N3O3
MW: 265.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight265.31
XLogP30.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Exact Mass265.14264148
Monoisotopic Mass265.14264148
Topological Polar Surface Area91.3 Ų
Heavy Atom Count19
Formal Charge0
Complexity284
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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