Pyroxamide

• Description :

  Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Apoptosis; HDAC

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pyroxamide.html

• Purity :

  99.54

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(NO)CCCCCCC(NC1=CC=CN=C1)=O

• Molecular Formula :

  C13H19N3O3

• Molecular Weight :

  265.31

• Precautions :

  H302

• References & Citations :

  [1]Butler LM, et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin Cancer Res. 2001 Apr;7 (4) :962-70.|[2]Kutko MC, et al. Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro.Clin Cancer Res. 2003 Nov 15;9 (15) :5749-55.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  HDAC1

• CAS Number :

  [382180-17-8]