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Pyroxamide

CAT: 0804-HY-13216-01Size: 5 mgDry Ice: NoHazardous: No
CAT#: HY-13216-01Size: 5 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia[1].
CAS Number
[382180-17-8]
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pyroxamide.html
Purity
99.54
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NO)CCCCCCC(NC1=CC=CN=C1)=O
Molecular Formula
C13H19N3O3
Molecular Weight
265.31
Precautions
H302
References & Citations
[1]Butler LM, et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin Cancer Res. 2001 Apr;7 (4) :962-70.|[2]Kutko MC, et al. Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro.Clin Cancer Res. 2003 Nov 15;9 (15) :5749-55.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
HDAC1

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