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DAURK-4

CAT: 0804-HY-137344Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-137344Size:1 Each
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Description
DAURK-4, an Alisertib derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 has anticancer effects[1].
CAS Number
2705844-81-9
UNSPSC
12352005
Target
Aurora Kinase; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/daurk-4.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C1C(NC(CC1)=O)=O)C2=O)C3=C2C=CC=C3OCC(NCCCOCCOCCOCCCNC(C4=CC=C(NC5=NC=C6C(C(C=CC(Cl)=C7)=C7C(C8=C(F)C=CC=C8OC)=NC6)=N5)C=C4OC)=O)=O
Molecular Formula
C52H52ClFN8O12
Molecular Weight
1035.47
References & Citations
[1]Katherine A Donovan, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183 (6) :1714-1731.e10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A

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