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PF-5081090

CAT: 0804-HY-103251-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103251-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-5081090 (LpxC-4) is a potent LpxC inhibitor, is a rapidly bactericidal with broad-spectrum activity. PF-5081090 serves as a regulator of lipid A biosynthesis in Gram-negative pathogens[1][2].
CAS Number
1312473-63-4
Product Name Alternative
LpxC-4
UNSPSC
12352005
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pf-5081090.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(C2=CC(N(CC[C@](S(C)(=O)=O)(C)C(NO)=O)C=C2)=O)C=CC(OC)=C1
Molecular Formula
C18H21FN2O6S
Molecular Weight
412.43
References & Citations
[1]Tomaras AP, et al. LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens. mBio. 2014 Sep 30;5 (5) :e01551-14.|[2]García-Quintanilla M, et al. Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii. Antimicrob Agents Chemother. 2016 Jul 22;60 (8) :5076-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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