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BLM-IN-1

CAT: 0804-HY-111756-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111756-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BLM-IN-1 is an effective bloom syndrome protein (BLM) inhibitor. BLM-IN-1 has a high binding affinity with a KD valueof 1.81 μM. BLM-IN-1 has good inhibitory effect for BLM with an IC50 value of 0.95 μM. BLM-IN-1 can induce cell apoptosis. BLM-IN-1can be used for the research of DNA damage and cancer[1].
CAS Number
2056014-40-3
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BLM-IN-1.html
Concentration
10mM
Purity
98.04
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
CCN(CC)CCCNC1=CC(N=C(/C(CC2)=C/C3=CC=C(C(C)C)C=C3)N2C4=O)=C4C=C1F
Molecular Formula
C28H35FN4O
Molecular Weight
462.60
References & Citations
[1]Yin QK, et al. Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. J Med Chem. 2019 Mar 28;62 (6) :3147-3162.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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