Hematin

CAT: 0804-HY-W040030Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W040030Size:100 mg
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Description
Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins[1]. Hematin can be used for the research of acute porphyrias and cancer[1][2][3][4][5].
CAS Number
[15489-90-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hematin.html
Purity
98.09
Solubility
DMSO : 1.43 mg/mL (ultrasonic; warming; heat to 70°C)
Smiles
CC1=C(CCC(O)=O)C([N-]C1=CC(C(C)=C2C=C)=NC2=CC3=C4C)=CC(C(CCC(O)=O)=C5C)=NC5=CC([N-]3)=C4C=C.[Fe+3].[OH-]
Molecular Formula
C34H33FeN4O5
Molecular Weight
633.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Siegert SW, et al. Physicochemical properties, pharmacokinetics, and pharmacodynamics of intravenous hematin: a literature review. Adv Ther. 2008 Sep;25 (9) :842-57.|[2]Green D, et al. The inactivation of hemostatic factors by hematin. J Lab Clin Med. 1983;102: 361-369.|[3]Amin ML, et al. Development of hematin conjugated PLGA nanoparticle for selective cancer targeting. Eur J Pharm Sci. 2016 Aug 25;91:138-43.|[4]Goetsch C, et al. Instability of hematin used in the treatment of acute hepatic porphyria. N Engl J Med. 1986;315: 235-238.|[5]Quadros HC, et al. The Role of the Iron Protoporphyrins Heme and Hematin in the Antimalarial Activity of Endoperoxide Drugs. Pharmaceuticals (Basel) . 2022;15 (1) :60. Published 2022 Jan 4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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