Hematein (Standard)

• Description:

  Hematein (Standard) is the analytical standard of Hematein. This product is intended for research and analytical applications. Hematein is a oxidation product of hematoxylin acted as a dye[1]. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells[2].

• UNSPSC:

  12352100

• Target:

  Akt; Apoptosis; Casein Kinase; Reference Standards; Wnt

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  O=C1C=C2CC3(C(C4=CC=C(C(O)=C4OC3)O)=C2C=C1O)O

• Molecular Formula:

  C16H12O6

• Molecular Weight:

  300.26

• References & Citations:

  [1]Shirai, K., & Matsuoka, M. (1996) . Structure and properties of hematein derivatives. Dyes and Pigments, 32 (3), 159–169.|[2]Hung MS, et al. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograftmodel.Int J Oncol. 2013 Nov;43 (5) :1517-22.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [475-25-2]