Hemin

• Description :

  Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO) -1 inducer.

• Product Name Alternative :

  Hemin chloride

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Autophagy; Ferroptosis; Mitophagy

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Autophagy

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/Hemin.html

• Purity :

  99.59

• Solubility :

  1M NaOH : 6.67 mg/mL (ultrasonic; adjust pH to 12 with NaOH) |H2O : < 0.1 mg/mL

• Smiles :

  [Cl-][Fe+3]123[N-]4C5=C(CCC(O)=O)C(C)=C4C=C(C(C=C)=C6C)[N]1=C6C=C(C(C=C)=C7C)[N-]2C7=CC(C(C)=C8CCC(O)=O)=[N]3C8=C5

• Molecular Formula :

  C34H32ClFeN4O4

• Molecular Weight :

  651.94

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Vanova K, et al. Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells. BMC Cancer. 2016 May 12;16:309.|[2]Chen HH, et al. Heme oxygenase-1 ameliorates kidney ischemia-reperfusion injury in mice through extracellular signal-regulated kinase 1/2-enhanced tubular epithelium proliferation. Biochim Biophys Acta. 2015 Oct;1852 (10 Pt A) :2195-201.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• CAS Number :

  [16009-13-5]