Hemin

• Description:

  Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO) -1 inducer.

• Product Name Alternative:

  Hemin chloride

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Autophagy; Ferroptosis; Mitophagy

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Autophagy

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Hemin.html

• Purity:

  99.59

• Solubility:

  1M NaOH : 6.67 mg/mL (ultrasonic; adjust pH to 12 with NaOH) |H2O : < 0.1 mg/mL

• Smiles:

  [Cl-][Fe+3]123[N-]4C5=C(CCC(O)=O)C(C)=C4C=C(C(C=C)=C6C)[N]1=C6C=C(C(C=C)=C7C)[N-]2C7=CC(C(C)=C8CCC(O)=O)=[N]3C8=C5

• Molecular Formula:

  C34H32ClFeN4O4

• Molecular Weight:

  651.94

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Vanova K, et al. Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells. BMC Cancer. 2016 May 12;16:309.|[2]Chen HH, et al. Heme oxygenase-1 ameliorates kidney ischemia-reperfusion injury in mice through extracellular signal-regulated kinase 1/2-enhanced tubular epithelium proliferation. Biochim Biophys Acta. 2015 Oct;1852 (10 Pt A) :2195-201.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• CAS Number:

  [16009-13-5]