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LY2794193

CAT: 0804-HY-119243-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-119243-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY2794193 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM, EC50=0.47 nM; hmGlu2 Ki=412 nM, EC50=47.5 nM) [1].
CAS Number
2173037-97-1
Product Name Alternative
2'-3'-cyclic GMP-AMP, 2'-3'-cyclic GMP-AMP (sodium)
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/LY2794193.html
Purity
99.65
Solubility
DMSO : 200 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; adjust pH to 14 with NaOH)
Smiles
O=C([C@@]1(N)[C@]2([H])[C@@H](C(O)=O)[C@]2([H])[C@@H](NC(C3=CC=CC(OC)=C3)=O)C1)O
Molecular Formula
C16H18N2O6
Molecular Weight
334.32
References & Citations
[1]Monn JA, et al. Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S) -2-Amino-4-[ (3-methoxybenzoyl) amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist. J Med Chem. 2018 Mar 22;61 (6) :2303-2328.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR2; mGluR3

Chemical Information

(1S,2S,4S,5R,6S)-2-amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CAS Number2173037-97-1
PubChem CID60096231
IUPAC Name(1S,2S,4S,5R,6S)-2-amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Molecular FormulaC16H18N2O6
Molecular Weight334.32
XLogP-2.6
Topological Polar Surface Area139
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count24
Formal Charge0
Complexity567
SMILES
COC1=CC=CC(=C1)C(=O)N[C@H]2C[C@]([C@H]3[C@@H]2[C@@H]3C(=O)O)(C(=O)O)N
InChI
InChI=1S/C16H18N2O6/c1-24-8-4-2-3-7(5-8)13(19)18-9-6-16(17,15(22)23)12-10(9)11(12)14(20)21/h2-5,9-12H,6,17H2,1H3,(H,18,19)(H,20,21)(H,22,23)/t9-,10-,11-,12-,16-/m0/s1
InChIKey
UXNRHIJPZNNDDJ-VZAVHYRXSA-N
Chemical Structure
2D Structure
2D structure of (1S,2S,4S,5R,6S)-2-amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CAS: 2173037-97-1
CID: 60096231
Formula: C16H18N2O6
MW: 334.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight334.32
XLogP3-2.6
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass334.11648630
Monoisotopic Mass334.11648630
Topological Polar Surface Area139 Ų
Heavy Atom Count24
Formal Charge0
Complexity567
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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T15807LY2794193
A19131-25LY2794193 25mg
A19131-100LY2794193 100mg
A19131-5LY2794193 5mg
A19131-50LY2794193 50mg
A19131-10LY2794193 10mg

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