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LY2794193

CAT: 0804-HY-119243-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119243-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY2794193 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM, EC50=0.47 nM; hmGlu2 Ki=412 nM, EC50=47.5 nM) [1].
CAS Number
2173037-97-1
Product Name Alternative
2'-3'-cyclic GMP-AMP, 2'-3'-cyclic GMP-AMP (sodium)
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/LY2794193.html
Purity
99.65
Solubility
DMSO : 200 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; adjust pH to 14 with NaOH)
Smiles
O=C([C@@]1(N)[C@]2([H])[C@@H](C(O)=O)[C@]2([H])[C@@H](NC(C3=CC=CC(OC)=C3)=O)C1)O
Molecular Formula
C16H18N2O6
Molecular Weight
334.32
References & Citations
[1]Monn JA, et al. Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S) -2-Amino-4-[ (3-methoxybenzoyl) amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist. J Med Chem. 2018 Mar 22;61 (6) :2303-2328.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR2; mGluR3

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