BMS-1233

• Target:

  PD-1/PD-L1

• Related Pathways:

  Immunology/Inflammation|||Apoptosis|||Cell Cycle/Checkpoint

• Bioactivity:

  BMS-1233 is an orally effective programmed death ligand 1 (PD-L1) inhibitor with an IC50 of 14.5 nM. This compound promotes the death of HepG2 cells in a co-culture model with Jurkat T cells and exhibits antitumor activity against melanoma in mouse models.

• Smiles:

  N#CC1=CC=CC(=C1)COC2=CC(OCC3=CC=CC(C=4C=CC=CC4)=C3C)=C(Cl)C=C2CN5CCCCC5C(=O)O

• Molecular Formula:

  C35H33ClN2O4

• Molecular Weight:

  581.1

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2447065-99-6