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DBCO-PEG5-NHS ester

CAT:
804-HY-126885-03
Size:
25 mg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
DBCO-PEG5-NHS ester - image 1

DBCO-PEG5-NHS ester

  • CAS Number: 2144395-59-3
  • UNSPSC Description: DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2]. DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
  • Target Antigen: ADC Linker; PROTAC Linkers
  • Type: ADC Related
  • Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
  • Field of Research: Cancer
  • Assay Protocol: https://www.medchemexpress.com/dbco-peg5-nhs-ester.html
  • Purity: 95.06
  • Solubility: DMSO : ≥ 100 mg/mL
  • Smiles: O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCNC(CCC(N2C3=CC=CC=C3C#CC4=CC=CC=C4C2)=O)=O
  • Molecular Weight: 693.74
  • References & Citations: [1]Craig L. Duvall, et al. Conjugation of lipophilic albumin-binding moiety to rna for improved carrier-free in vivo pharmacokinetics and gene silencing. US20180064749A1.|[2]Samantha M Sarett, et al. Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6490-E6497.
  • Shipping Conditions: Blue Ice
  • Storage Conditions: -20°C (Powder, sealed storage, away from moisture and light)
  • Clinical Information: No Development Reported