Bis-PEG5-NHS ester

• Description :

  Bis-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

• UNSPSC :

  12352203

• Hazard Statement :

  H302, H317

• Target :

  ADC Linker; PROTAC Linkers

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bis-peg5-nhs-ester.html

• Purity :

  99.83

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O

• Molecular Formula :

  C22H32N2O13

• Molecular Weight :

  532.50

• Precautions :

  H302, H317

• References & Citations :

  [1]Hans-Georg Lerchen, et al. Prodrugs of cytotoxic active agents having enzymatically cleavable groups. WO2018114798A1.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Alkyl/ether Linkers; Cleavable Linker; PEG Linkers

• CAS Number :

  [756526-03-1]