PJ34

CAT: 0804-HY-13688A-02Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-13688A-02Size:10 mg

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Description

PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively.

CAS Number

344458-19-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pj34.html

Purity

98.11

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC(C=C1C2=C3C=CC=C2)=CC=C1NC3=O)CN(C)C

Molecular Formula

C17H17N3O2

Molecular Weight

295.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Iwashita A, et al. A novel and potent poly (ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3- (4-phenyl-3,6-dihydro-1 (2H) -pyridinyl) propyl]-4 (3H) -quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. J Ph|[2]Haddad M, et al. Anti-inflammatory effects of PJ34, a poly (ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. Br J Pharmacol. 2006 Sep;149 (1) :23-30.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PARP; PARP1; PARP2

Citation 01

Chemical Information

PJ-34

PJ34 is a member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties. It has a role as an antiatherosclerotic agent, an antineoplastic agent, an angiogenesis inhibitor, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and a cardioprotective agent. It is a secondary carboxamide, a tertiary amino compound and a member of phenanthridines. It is a conjugate base of a PJ34(1+).

CAS Number	344458-19-1
PubChem CID	4858
IUPAC Name	2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide
Molecular Formula	C17H17N3O2
Molecular Weight	295.34
XLogP	1.7
Topological Polar Surface Area	61.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	22
Formal Charge	0
Complexity	438

SMILES

CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32

InChI

InChI=1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22)

InChIKey

UYJZZVDLGDDTCL-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 344458-19-1

CID: 4858

Formula: C17H17N3O2

MW: 295.34

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	295.34
XLogP3	1.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	295.132076794
Monoisotopic Mass	295.132076794
Topological Polar Surface Area	61.4 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	438
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
A3729-5	PJ34
A4159-5.1	PJ34 hydrochloride
MBS577330	PJ34 HCl
A15215-25	PJ34 25mg
A15215-10	PJ34 10mg

PJ34

Chemical Information

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