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PJ34

CAT: 0127-BUP06930-04Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0127-BUP06930-04Size:100 mg
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CAS Number
344458-19-1
Purity
=95%
Smiles
CN(C)CC(=O)Nc1ccc2[nH]c(=O)c3ccccc3c2c1

Chemical Information

PJ-34

PJ34 is a member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties. It has a role as an antiatherosclerotic agent, an antineoplastic agent, an angiogenesis inhibitor, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and a cardioprotective agent. It is a secondary carboxamide, a tertiary amino compound and a member of phenanthridines. It is a conjugate base of a PJ34(1+).

CAS Number344458-19-1
PubChem CID4858
IUPAC Name2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide
Molecular FormulaC17H17N3O2
Molecular Weight295.34
XLogP1.7
Topological Polar Surface Area61.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity438
SMILES
CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32
InChI
InChI=1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22)
InChIKey
UYJZZVDLGDDTCL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PJ-34
CAS: 344458-19-1
CID: 4858
Formula: C17H17N3O2
MW: 295.34
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight295.34
XLogP31.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass295.132076794
Monoisotopic Mass295.132076794
Topological Polar Surface Area61.4 Ų
Heavy Atom Count22
Formal Charge0
Complexity438
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M18454-01PJ34
A15215-25PJ34 25mg
A15215-10PJ34 10mg
MBS577330PJ34 HCl
A4159-5.1PJ34 hydrochloride

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