IFSP1

• Description :

  IFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R) -RSL3 (HY-100218A) [1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H315, H319, H332, H335

• Target :

  Ferroptosis; Ligands for Target Protein for PROTAC

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ifsp1.html

• Purity :

  99.96

• Solubility :

  DMSO : 11.67 mg/mL (ultrasonic)

• Smiles :

  N#CC1=C(N)N2C3=CC=CC=C3N=C2C(C#N)=C1C4=CC=C(C)C=C4

• Molecular Formula :

  C20H13N5

• Molecular Weight :

  323.35

• Precautions :

  H302, H312, H315, H319, H332, H335

• References & Citations :

  [1]Doll S, et al. FSP1 is a glutathione-independent ferroptosis suppressor.Nature. 2019 Nov;575 (7784) :693-698.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [150651-39-1]