AS 1411

CAT: 0804-HY-147081-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-147081-01Size:1 mg
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Description
AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity[1][2][3].
CAS Number
[301636-59-9]
Product Name Alternative
AGRO-100
UNSPSC
12352208
Target
Bcl-2 Family; Histone Methyltransferase
Type
Oligonucleotides
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/as-1411.html
Purity
99.52
Solubility
10 mM in H2O
Smiles
[AS1411]
Molecular Weight
8272.31
References & Citations
[1]Teng Y, et al. AS1411 alters the localization of a complex containing protein arginine methyltransferase 5 and nucleolin. Cancer Res. 2007;67 (21) :10491-10500. |[2]Soundararajan S, et al. The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cells. Cancer Res. 2008;68 (7) :2358-2365. |[3]Mohammad T Malik, et al. AS1411-conjugated gold nanospheres and their potential for breast cancer therapy. Oncotarget. 2015 Sep 8;6 (26) :22270-81.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 2
Isoform
Bcl-2
Citation 01
Int J Pharm X. 2025 Jun.|Phytomedicine. 2025 Jun 2:144:156932.

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