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Moclobemide-d8

CAT: 0804-HY-B0534SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0534SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Moclobemide-d8 (Ro111163-d8) is the deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A[1].Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.
CAS Number
2309010-25-9
Product Name Alternative
Ro111163-d8
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Monoamine Oxidase
Type
Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling; Others
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
O=C(NCCN1C([2H])([2H])C([2H])([2H])OC([2H])([2H])C1([2H])[2H])C2=CC=C(Cl)C=C2
Molecular Formula
C13H9D8ClN2O2
Molecular Weight
276.79
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Nafiz Öncü Can, et al. Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity. Molecules. 2017 Aug 20;22 (8) :1381.|[3]Yun-feng Li, et al. Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice. Acta Pharmacol Sin. 2004 Nov;25 (11) :1408-12.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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