Netarsudil (hydrochloride)
CAT:
804-HY-12798B-03
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Netarsudil (hydrochloride)
- Product Name Alternative: AR-13324 (hydrochloride)
- CAS Number: 1253952-02-1
- UNSPSC Description: Netarsudil hydrochloride (AR-13324 hydrochloride) is a Rho-associated protein kinas (ROCK) and norepinephrine transporter (NET) inhibitor. Netarsudil hydrochloride has effective in intraocular pressure (IOP) reduction[1][2].
- Target Antigen: ROCK
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/Netarsudil_hydrochloride.html
- Purity: 99.77
- Solubility: DMSO : 5 mg/mL (ultrasonic)
- Smiles: CC1=CC(C)=C(C(OCC2=CC=C([C@@H](CN)C(NC3=CC(C=CN=C4)=C4C=C3)=O)C=C2)=O)C=C1.[H]Cl.[H]Cl
- Molecular Weight: 526.45
- References & Citations: [1]Wang RF, et al. Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24(1):51-54.|[2]Kiel JW, et al. Effect of AR-13324 on episcleral venous pressure in Dutch belted rabbits. J Ocul Pharmacol Ther. 2015 Apr;31(3):146-151.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched