Netarsudil (hydrochloride)

• Product Name Alternative:

  AR-13324 (hydrochloride)

• CAS Number:

  1253952-02-1

• UNSPSC Description:

  Netarsudil hydrochloride (AR-13324 hydrochloride) is a Rho-associated protein kinas (ROCK) and norepinephrine transporter (NET) inhibitor. Netarsudil hydrochloride has effective in intraocular pressure (IOP) reduction[1][2].

• Target Antigen:

  ROCK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Netarsudil_hydrochloride.html

• Purity:

  99.77

• Solubility:

  DMSO : 5 mg/mL (ultrasonic)

• Smiles:

  CC1=CC(C)=C(C(OCC2=CC=C([C@@H](CN)C(NC3=CC(C=CN=C4)=C4C=C3)=O)C=C2)=O)C=C1.[H]Cl.[H]Cl

• Molecular Weight:

  526.45

• References & Citations:

  [1]Wang RF, et al. Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24(1):51-54.|[2]Kiel JW, et al. Effect of AR-13324 on episcleral venous pressure in Dutch belted rabbits. J Ocul Pharmacol Ther. 2015 Apr;31(3):146-151.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched