Netarsudil

• Product Name Alternative:

  AR-13324

• CAS Number:

  1254032-66-0

• UNSPSC Description:

  Netarsudil is a Rho kinase (ROCK) and norepinephrine transporter (NET) inhibitor. Netarsudil increases outflow facility in human eyes through multiple mechanisms[1].

• Target Antigen:

  Monoamine Transporter; ROCK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton;Membrane Transporter/Ion Channel;Stem Cell/Wnt;TGF-beta/Smad

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/netarsudil.html

• Purity:

  98.78

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  CC1=CC(C)=C(C(OCC2=CC=C([C@@H](CN)C(NC3=CC(C=CN=C4)=C4C=C3)=O)C=C2)=O)C=C1

• Molecular Weight:

  453.53

• References & Citations:

  [1]Ren R, et al. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6197-6209.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched