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3-Hydroxyflunitrazepam

CAT: 0804-HY-121057-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121057-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
3-Hydroxyflunitrazepam (3-OH FNTZ) is the major metabolite of Flunitrazepam (FNTZ), generated via 3-hydroxylation by CYP3A4 (Km = 286 μM), and represents the dominant metabolic pathway (>80%) in liver microsomes. Its formation is significantly inhibited by CYP3A4 inhibitors such as Ketoconazole (IC50 = 0.11 μM) and Ritonavir (HY-90001) (IC50 = 0.041 μM), indicating a strong dependence on CYP3A4 activity and potential drug interactions[1].
CAS Number
67739-71-3
Product Name Alternative
3-OH FNTZ
UNSPSC
12352005
Target
Cytochrome P450; Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/3-hydroxyflunitrazepam.html
Smiles
O=C1C(O)N=C(C2=CC=CC=C2F)C3=CC([N+]([O-])=O)=CC=C3N1C
Molecular Formula
C16H12FN3O4
Molecular Weight
329.28
References & Citations
[1]Hesse LM, et al. CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam. Drug Metab Dispos. 2001 Feb;29 (2) :133-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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