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IMDK

CAT: 0804-HY-110171-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110171-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IMDK is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK) . iMDK suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice[1].
CAS Number
881970-80-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/imdk.html
Purity
99.35
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C1C(C2=CN3C(SC(CC4=CC=C(F)C=C4)=C3)=N2)=CC5=CC=CC=C5O1
Molecular Formula
C21H13FN2O2S
Molecular Weight
376.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Naomasa Ishida, et al. A novel PI3K inhibitor iMDK suppresses non-small cell lung Cancer cooperatively with A MEK inhibitor. Exp Cell Res. 2015 Jul 15;335 (2) :197-206.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Cell Discov. 2024 Oct 22;10 (1) :110.|IUBMB Life. 2025 May;77 (5) :e70014.|Nat Commun. 2023 Jul 31;14 (1) :4600.

Chemical Information

3-[2-(4-fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl]-2H-chromen-2-one
CAS Number881970-80-5
PubChem CID15991416
IUPAC Name3-[2-[(4-fluorophenyl)methyl]imidazo[2,1-b][1,3]thiazol-6-yl]chromen-2-one
Molecular FormulaC21H13FN2O2S
Molecular Weight376.4
XLogP5.6
Topological Polar Surface Area71.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity607
SMILES
C1=CC=C2C(=C1)C=C(C(=O)O2)C3=CN4C=C(SC4=N3)CC5=CC=C(C=C5)F
InChI
InChI=1S/C21H13FN2O2S/c22-15-7-5-13(6-8-15)9-16-11-24-12-18(23-21(24)27-16)17-10-14-3-1-2-4-19(14)26-20(17)25/h1-8,10-12H,9H2
InChIKey
IWFKQTWYILKFGE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-[2-(4-fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl]-2H-chromen-2-one
CAS: 881970-80-5
CID: 15991416
Formula: C21H13FN2O2S
MW: 376.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight376.4
XLogP35.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass376.06817700
Monoisotopic Mass376.06817700
Topological Polar Surface Area71.8 Ų
Heavy Atom Count27
Formal Charge0
Complexity607
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
5126/50iMDK
T61627-01IMDK quarterhydrate
217548Midkine Inhibitor, iMDK (MDK Expression Inhibitor, 3- (2- (4-Fluorobenzyl) imidazo[2,1-b]thiazol-6-yl) -2H-chromen-2-one, 3- (2- (4-Fluorobenzyl) imidazo[2,1-b][1,3]thiazol-6-yl) -2H-chromen-2-one)

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