IMD-catechol

• Description:

  IMD-catechol is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves efficacy in a CT26 mouse colon carcinoma tumor model while eliciting minimal adjuvant toxicity.

• UNSPSC:

  12352005

• Target:

  NF-κB

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/imd-catechol.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=NC(C=CC=C2)=C2C3=C1N=C(CCCC)N3CC4=CC=C(CNC(NCCC5=CC(O)=C(O)C=C5)=O)C=C4

• Molecular Formula:

  C31H34N6O3

• Molecular Weight:

  538.64

• References & Citations:

  [1]Kimani FW, et al. Improving the Adjuvanticity of Small Molecule Immune Potentiators Using Covalently Linked NF-κB Modulators. ACS Med Chem Lett. 2021 Aug 26;12 (9) :1441-1448.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NF-κB

• CAS Number:

  [2928463-39-0]