IMD-catechol

CAT: 0804-HY-139716Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-139716Size:1 Each
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Description
IMD-catechol is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves efficacy in a CT26 mouse colon carcinoma tumor model while eliciting minimal adjuvant toxicity.
CAS Number
[2928463-39-0]
UNSPSC
12352005
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/imd-catechol.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(C=CC=C2)=C2C3=C1N=C(CCCC)N3CC4=CC=C(CNC(NCCC5=CC(O)=C(O)C=C5)=O)C=C4
Molecular Formula
C31H34N6O3
Molecular Weight
538.64
References & Citations
[1]Kimani FW, et al. Improving the Adjuvanticity of Small Molecule Immune Potentiators Using Covalently Linked NF-κB Modulators. ACS Med Chem Lett. 2021 Aug 26;12 (9) :1441-1448.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NF-κB

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