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TDRL-X80

CAT: 0804-HY-139038-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139038-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TDRL-X80 is a potent inhibitor of xeroderma pigmentosum group A (XPA) protein. TDRL-X80 inhibits XPA’s DNA binding activity. TDRL-X80 exhibits activity against single, double, and Cisplatin-damaged DNA with IC50s of 18, 20, and 29 μM in fluorescence polarization (FP) analyses , and with IC50s of 21, 39, and 28 in ELISA Analysis[1].
CAS Number
292065-64-6
UNSPSC
12352005
Hazard Statement
H302, H413
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tdrl-x80.html
Purity
99.6
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=CC(C2=CC=C(/C=C3C(C)=NN(C4=CC=CC(C(O)=O)=C4)C\3=O)O2)=CC=C1Cl
Molecular Formula
C23H15ClN2O6
Molecular Weight
450.83
Precautions
H302, H413
References & Citations
[1]Tracy M Neher, et al. Identification of novel small molecule inhibitors of the XPA protein using in silico based screening. ACS Chem Biol. 2010 Oct 15;5 (10) :953-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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