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Ebastine-d6

CAT: 0804-HY-B0674S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0674S1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ebastine-d6 is deuterated labeled Ebastine. Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research[1].
Product Name Alternative
LAS-W 090-d6; RP64305-d6
UNSPSC
12352005
Target
Histamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C=C1)C(C)(C)C)CCCN(CC2)CCC2OC(C3=CC=CC=C3)([2H])C4=C([2H])C([2H])=C([2H])C([2H])=C4[2H]
Molecular Formula
C32H33D6NO2
Molecular Weight
475.69
References & Citations
[1]Fu-Ming Tsai, et al. Extracellular Signal-Regulated Kinase Mediates Ebastine-Induced Human Follicle Dermal Papilla Cell Proliferation. Biomed Res Int. 2019 Feb 11;2019:6360503.|[2]J Sastre. Ebastine in allergic rhinitis and chronic idiopathic urticarial. Allergy. 2008 Dec;63 Suppl 89:1-20.|[3]Fujii, et al. Absorption, distribution, metabolism and excretion of [14C]ebastine after a single administration in rats. Arzneimittelforschung. 1994 Apr;44 (4) :527-38.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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