Ebastine

• Description :

  Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research[1].

• Product Name Alternative :

  LAS-W 090; RP64305

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H413

• Target :

  Histamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/Ebastine.html

• Concentration :

  10mM

• Purity :

  99.96

• Solubility :

  DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 58.75 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC=C(C(C)(C)C)C=C1)CCCN2CCC(OC(C3=CC=CC=C3)C4=CC=CC=C4)CC2

• Molecular Formula :

  C32H39NO2

• Molecular Weight :

  469.66

• Precautions :

  H302, H413

• References & Citations :

  [1]J Sastre. Ebastine in allergic rhinitis and chronic idiopathic urticarial. Allergy. 2008 Dec;63 Suppl 89:1-20.|[2]Fu-Ming Tsai, et al. Extracellular Signal-Regulated Kinase Mediates Ebastine-Induced Human Follicle Dermal Papilla Cell Proliferation. Biomed Res Int. 2019 Feb 11;2019:6360503.|[3]Fujii, et al. Absorption, distribution, metabolism and excretion of [14C]ebastine after a single administration in rats. Arzneimittelforschung. 1994 Apr;44 (4) :527-38.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  H1 Receptor

• CAS Number :

  [90729-43-4]