Ebastine

• Description:

  Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research[1].

• Product Name Alternative:

  LAS-W 090; RP64305

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H413

• Target:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/Ebastine.html

• Concentration:

  10mM

• Purity:

  99.96

• Solubility:

  DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 58.75 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=CC=C (C (C) (C) C) C=C1) CCCN2CCC (OC (C3=CC=CC=C3) C4=CC=CC=C4) CC2

• Molecular Formula:

  C32H39NO2

• Molecular Weight:

  469.66

• Precautions:

  H302, H413

• References & Citations:

  [1]J Sastre. Ebastine in allergic rhinitis and chronic idiopathic urticarial. Allergy. 2008 Dec;63 Suppl 89:1-20.|[2]Fu-Ming Tsai, et al. Extracellular Signal-Regulated Kinase Mediates Ebastine-Induced Human Follicle Dermal Papilla Cell Proliferation. Biomed Res Int. 2019 Feb 11;2019:6360503.|[3]Fujii, et al. Absorption, distribution, metabolism and excretion of [14C]ebastine after a single administration in rats. Arzneimittelforschung. 1994 Apr;44 (4) :527-38.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  H1 Receptor

• CAS Number:

  90729-43-4