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TRAIL Human (114-281 a.a.), Active

CAT: 0793-32-6589-2Size: 2 µgDry Ice: NoHazardous: No
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CAT#:0793-32-6589-2Size:2 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Source: Escherichia Coli.Sterile Filtered colorless liquid.TNF-related apoptosis-inducing ligand (TRAIL) is a ligand molecule which induces apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family.In humans, the gene that encodes for TRAIL is located at chromosome 3q26.TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is caspase-8-dependent. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues.Soluble TNF-related apoptosis-inducing ligand Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids (114-281) and having a molecular mass of 19.6 kDa. The sTRAIL is purified by proprietary chromatographic techniques.
Product Name Alternative
Tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis-inducing ligand, Protein TRAIL, Apo-2 ligand, Apo-2L, CD253 antigen, TL2, APO2L, TNFSF10.
Applications
Functional Assay
Purification
Greater than 95.0% as determined by SDS-PAGE.
Components
TRAIL protein solution (1mg/mL) containing 20mM Tris-HCl pH-7.5, 300mM NaCl, 0.1mM DTT & 10% glycerol.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Avoid multiple freeze-thaw cycles.
Applications Notes
Measured in a cell cytotoxicity assay using Jurkat human T lymphocyte. The ED50 for this effect is less or equal to 1 ng/ml.
Amino Acids
MVRERGPQRV AAHITGTRGR SNTLSSPNSK NEKALGRKIN SWESSRSGHS FLSNLHLRNGELVIHEKGFY YIYSQTYFRF QEEIKENTKN DKQMVQYIYK YTSYPDPILL MKSARNSCWSKDAEYGLYSI YQGGIFELKE NDRIFVSVTN EHLIDMDHEA SFFGAFLVG.

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Alternative Products

CatalogName
OM297072-01TRAIL Human (114-281 a.a.), Active
GTR18985257-01Human TRAIL (114-281 a.a.) (Active) Protein
rAP-0756TRAIL/APO 2 Ligand (114-281 a.a.) Human Recombinant, Active
TNFSF10-03HActive Recombinant Human TNFSF10 Protein (114-281), Tag-Free
PROTP50591-2a.a.), TRAIL/APO 2 Ligand (114-281 a.a.) Human Recombinant Protein, Active
MBS147041-01Recombinant Human TNF-Related Apoptosis Inducing Ligand/Apo2L (114-281), Active
587048-01Tumor Necrosis Factor Ligand Superfamily Member 10, Active, Recombinant, Human, aa115-281 (TNFSF10)
586853-01C-X-C motif chemokine 5, Active, Recombinant, Human, aa44-114 (CXCL5) discontinued
587053-01Tumor Necrosis Factor Ligand Superfamily Member, Active, Recombinant, Human, His-Tag, aa114-281 (TNFSF10) discontinued
cyt-1014-01TRAIL (114-281 a.a.) Active

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