Pomalidomide-PEG4-C-COOH

• UNSPSC Description:

  Pomalidomide-PEG4-C-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/14-__2-_2,6-dioxopiperidin-3-yl_-1,3-dioxoisoindolin-4-yl_amino_-3,6,9,12-tetraoxatetradecan-1-oic_acid.html

• Purity:

  99.10

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)|Ethanol : 25 mg/mL (ultrasonic)

• Smiles:

  O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3NCCOCCOCCOCCOCC(O)=O

• Molecular Weight:

  507.49

• References & Citations:

  [1]Guangrong Zheng, et al. Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof. WO2017184995A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  2097938-44-6